SOC Code - Visa Requirements: 2119
Interview Date: Friday 12 March 2021
Epigenetics of gene expression bursting during cancer metastasis
Gene expression is regulated by epigenetic mechanisms that enable a coordinate amount of RNA to be produced at specific times and in specific amounts in different tissues. Active genes are not expressed continuously, but instead undergo periods of “bursting” wherein they are active for a period of time and then silent until the next burst. Different genes can have different burst frequencies depending on their cellular environment.
The Murrell group at University of Bath is interested in understanding how such burst frequencies are epigenetically regulated.
The aim of this project is to examine the bursting kinetics of gene expression in normal cells, primary cancer cells and metastatic cells. MS2 labelling of RNA will be used to measuring transcriptional bursting and to correlate this with a range of epigenetic parameters such as DNA methylation, 5-hydroxymethylation, chromatin conformation and transcriptional interference by noncoding RNAs, under various growth conditions.
You will have a PhD and a strong background in epigenetic mechanisms of gene expression and transcriptional biology with a proven expertise in gene expression assays and intracellular RNA-tracking methodology such as MS2-tagging. Imaging experience of singe-molecule FISH techniques will be advantageous. Further essential skills include 3-dimentional cell culture and establishing organoids, as well as strong quantitative skills. A working knowledge of DNA methylation sequencing and CRISPR technologies is also required, and understanding of cancer biology and metastasis would be desirable.
The Department of Biology and Biochemistry is one of the leading research-intensive biosciences departments in the UK. We are a supportive and collaborative group highly experiences in mentoring and nurturing the careers of post doctoral and early career researchers. We have a Silver Athena SWAN award and are firmly committed to promoting equality and diversity
What we can offer you:
Our campus is surrounded by beautiful countryside, and the City of Bath with its historic charm and social activity only a short distance away creates an excellent environment in which to work.
We aim to be an inclusive university, where difference is celebrated, respected and encouraged. We truly believe that diversity of experience, perspectives, and backgrounds leads to a better environment for our employees and students, creating a learning environment and organisational culture that enhances health and wellbeing across our community. We are very proud to have recently received Ambassadors for Autism certification and are an accredited Disability Confident Leader; committed to building disability confidence and supporting disabled staff.
If you think you may require a visa to work in the UK you should refer to our applicant information webpage before embarking on a job application to ensure that you understand the requirements for sponsorship. You may be eligible to work in the UK via other alternative visa routes such as the Global Talent Visa or by having Settlement / ILR, please refer to our Staff Immigration webpages for further details.
The University of Bath is an equal opportunities employer and has an excellent international reputation with staff from over 60 different nations. We have made a positive commitment towards gender equality and intersectionality receiving a Bronze Athena SWAN award, and we are actively working towards a Silver award. We are a family-friendly University, with an increasingly agile workforce. We are open to flexible working arrangements and we’re also proud to be a disability confident employer and are happy to discuss any reasonable adjustments you may require.
|Salary:||£33,797 to £40,322 (Grade 7)|
|Placed On:||16th February 2021|
|Closes:||1st March 2021|