Postdoctoral Research Fellow - Targeting the DNA replication stress response in cancer

Job Overview

Location
Brighton, England
Job Type
Full Time
Date Posted
10 days ago

Additional Details

Job ID
10698
Job Views
15

Job Description

University of Sussex - Genome Damage and Stability Centre, School of Life Sciences

Location:Falmer
Salary:£33,797 to £40,322 Per annum
Hours:Full Time
Contract Type:Permanent
Placed On:17th February 2021
Closes:16th March 2021


Hoursfull time or part time hours considered up to a maximum of 1.0 FTE. Requests for flexible working options will be considered (subject to business need).

Closing date 16 March 2021. Applications must be received by midnight of the closing date.

Expected start date: ASAP

The School of Life Sciences is at the forefront of research in the biological sciences in the UK, coming in the top 10 in the REF 2014.

Based in the School of Life Sciences, the Genome Damage and Stability Centre  (http://www.sussex.ac.uk/gdsc/), is an internationally renowned Institute carrying out research on the response of cells to DNA damage, genome instability and its relationship to disease. We provide a stimulating and supportive environment and our expertise covers a range of experimental systems. An overview of research interests of the Rass lab can be found at https://www.sussex.ac.uk/lifesci/rasslab/.

A postdoctoral fellowship, funded by The Academy of Medical Sciences, is available immediately to study effector-level inhibition of the DNA replication stress response as a strategy to selectively kill cancer cells by stress-overload.

Replication stress is a hallmark of cancer and potential Achilles’ heel of the disease. The available project investigates the molecular mechanisms of the replication stress response in human cells, and how inhibiting critical effector proteins such as DNA2 (https://doi.org/10.1093/nar/gkaa524) can be exploited to eliminate cancer cells.

Candidates must have experience in human cell culture and CRISPR-Cas9-mediated genome editing, and should have a strong background in genome stability with evidence of independence and productivity (first authorship publication). This post is funded for 2 years initially.

Applications should be accompanied by a full CV, a statement of research interests and aspirations (up to a total of 4 pages), and the names of two academic referees. Informal enquiries are welcome and should be sent to Prof. Ulrich Rass at [email protected].

The University of Sussex values the diversity of its staff and students and we welcome applicants from all backgrounds

The School of Life Sciences is committed to increasing the diversity of its staff and providing an inclusive working environment. The School currently holds an Athena SWAN Silver Award, has developed a Race Equity Action Plan and hosts an active Equality, Diversity and Inclusion working group.

Applications are particularly welcomed from Black and minority ethnic candidates, and women, trans and non-binary candidates, who are under-represented in the School of Life Sciences.

Applications to posts from candidates who wish to work part-time or as job-sharers are welcome.

The University offers various schemes to provide real benefits to parents, these can be found at Family Friendly Policies

For full details and how to apply see our vacancies page

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