PhD Studentship: Modular DNA nanopore (NP) for targeted cell killing

Job Overview

Southampton, England
Job Type
Full Time
Date Posted
1 month ago

Additional Details

Job ID
Job Views

Job Description

University of Southampton

Qualification Type:PhD
Funding for:UK Students, EU Students
Funding amount:£36,718 to £48,937
Hours:Full Time
Placed On:16th February 2021
Closes:16th March 2021


Supervisory Team:    Dr Eugen Stulz (SoC), Dr Sean Lim (SoM)

Project description

We are seeking to recruit an enthusiastic PhD student as part of the H2020 MSCA Training Network “Oligonucleotides for Medical Applications - OLIGOMED”. You will join an international cohort of 15 ESR PhD student fellows researching key topics in the use of synthetic oligonucleotides (ONs) for medical applications, starting in June 2021.

The use of synthetic oligonucleotides (ONs, short DNA or RNA) in the treatment of genetic diseases is a rapidly growing field, and the most promising alternative to gene therapy using small molecules. You will be developing specific modified ONs for cancer treatment.

We have recently developed self-assembled DNA nanostructures that efficiently embed in lipid bilayers and cell membranes. The aim of this PhD project will be the development of a modular ON self-assembly system, which combines the membrane nanopores with adjustable targeting modules and therapeutic units. Having a single multifunctional and modular entity is a unique feature of our approach to develop a disruptive technology for personalised cancer medicine. You will also be undertaking functional assessment of the nanopores in a series of in vitro immunological assays within the newly built, state-of-the-art Centre for Cancer Immunology.

For this project, you will be enthusiastic to work in a multidisciplinary environment, apply and enhance what you have learned during your Masters degree in Chemistry, Chemical Biology or a related field, and contribute to a greater pan-European project.

You will benefit from a PhD project at the forefront of research, aimed at tackling a pressing need of society. You will have the opportunity to participate in a wide range of both scientific and transferable skills training. You will also be willing to travel across Europe for network wide training events, but most importantly for secondments (one to two months each) nationally and abroad. This will include an industrial placement at Sixfold Bioscience in London, and an academic placement in Udine (Italy). Additionally, through a strong collaboration with the School of Medicine (Southampton General Hospital, Cancer Centre) a significant part of the project will be conducted there.

If you wish to discuss any details of the project informally, please contact Eugen Stulz, Bioorganic and Materials Chemistry Research Group, Email: [email protected], Tel: +44 (0) 2380 59 9369.

Entry Requirements

Only candidates complying with the Early Stage Researcher requirements (less than 4 years of research experience following a graduation from a degree qualifying for entry to PhD) and mobility (less than 12 months spent in the UK within the last three years) are eligible.

Closing date: 16 March 2021.

Funding:. The position is fully funded for 3 years and includes a competitive salary, fees, and support for training and secondments. The salary range is £36,718 – £48,937. You must be eligible for home/EU (non-overseas) fees at the University of Southampton.

How To Apply

Apply online. Select programme type (Research), 2021/22, Faculty of Physical Sciences and Engineering, next page select “PhD Chemistry (Full time)”. In Section 2 of the application form you should insert the name of the supervisor Eugen Stulz (1336021EB).

You should also submit a completed online application form at

Applications should include:

Curriculum Vitae

Two reference letters

Degree Transcripts to date

For further information please contact: [email protected]

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