PhD Studentship: Modelling Metabolic Capability and Phylogeny of Host and Environmental Niche Adaptation in E. coli (MATHER_QDTP)

Job Overview

Location
Norwich, England
Job Type
Full Time
Date Posted
7 days ago

Additional Details

Job ID
6255
Job Views
12

Job Description

University of East Anglia - Norwich School of Medicine

Qualification Type:PhD
Location:Norwich
Funding for:UK Students, EU Students
Funding amount:£15,285 (2020/21 stipend rate)
Hours:Full Time
Placed On:14th October 2020
Closes:23rd November 2020


Location: Quadram Institute Bioscience

Start Date: 1 Oct 2021

Closing Date: 23 Nov 2020

Supervisor: Dr Alison Mather

Project Description: 

 The species Escherichia coli is a complex group of organisms which is found in a wide range of vertebrate animal hosts. The ability to colonise a given host is critical for E. coli and will require a different strategies, thus allowing for the evolution of separate lineages adapted to specific hosts. However, the high genetic diversity of E. coli means that detection of this niche adaptation is difficult. Given that there are multiple genotypic pathways to the same phenotypic endpoint, adaptation of E. coli to different host species may be more clearly observed by examination of phenotypes or metabolic pathways. 

This multidisciplinary project will define the variation in E. coli from different host species through genomic and phenotypic analysis. A new understanding of bacterial niche adaptation and novel computational tools will be developed. This project will include both wet lab and dry lab components, including growth assays, phylogenetics, and construction of computational metabolic models. You will develop skills in state-of-the-art genomics, bioinformatics, microbiology, and computational biology. 

You will join an interdisciplinary team that will support your training and development. Quadram Institute Bioscience provides a stimulating and supportive environment for research on bacterial genomics, microbiology, and the microbiome, and you will also work with One Health researchers at the Royal Veterinary College. You will have intellectual input into shaping the project and there will be opportunities to collaborate with partners both within and outside the institute to develop further skills and impact of the project. 

About NRP DTP:

The Norwich Research Park Biosciences Doctoral Training Partnership is open to UK and international candidates for entry October 2021 and offers postgraduates the opportunity to undertake a 4-year PhD research project whilst enhancing professional development and research skills through a comprehensive training programme. This project is short-listed for funding. 

Visit our website for further information: https://biodtp.norwichresearchpark.ac.uk/   

Person Specification: 

At least UK equivalence Bachelors (Honours) 2:1 or UK equivalence Master's degree. English Language requirement (Faculty of Science equivalent: IELTS 6.5 overall, 6 in each category). 

Funding Notes: 

This project is awarded with a 4-year Norwich Research Park Biosciences Doctoral Training Partnership (NRPDTP) PhD studentship. The studentship includes payment of tuition fees (directly to the University), a stipend for each year of the studentship (2020/21 stipend rate: £15,285), and a Research Training Support Grant for each year of the studentship of £5,000 p.a..

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