PhD Studentship: Metabolism of the Human Gut Symbiont Ruminoccocus Gnavus at the Mucosal Surface (JUGE_QDTP)

Job Overview

Norwich, England
Job Type
Full Time
Date Posted
7 days ago

Additional Details

Job ID
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Job Description

University of East Anglia - Biological Sciences

Qualification Type:PhD
Funding for:UK Students, EU Students
Funding amount:£15,285 (2020/21 stipend rate)
Hours:Full Time
Placed On:14th October 2020
Closes:23rd November 2020

Location: Quadram Institute Bioscience 

Start Date: 1 Oct 2021

Closing Date: 23 Nov 2020

Supervisor: Prof Nathalie Juge 

Project Description: 

This PhD studentship provides an exciting opportunity for the successful candidate to address fundamental questions on the spatial adaptation and metabolism of gut symbionts and acquire state-of-the art in both in silico and in vivo approaches. 

The human body harbours a diverse and dense population of commensal bacteria which exert key functions in terms of human health. However, the development of microbiome-targeted therapies to restore human health is currently hampered by a lack of mechanistic understanding of bacterial metabolism at the strain and niche level therefore limiting targeted approaches to achieve a clinically-desired effect. This work will define mechanisms of adaptation of key human gut symbionts to mucus and explore mucin glycan metabolism as novel strategies to target beneficial microbes at the strain level. 

The PhD student will join a dynamic multidisciplinary team at the Quadram Institute Bioscience and receive mentoring and training in relevant experimental models and state-of-the art bioinformatics tools. Through this PhD studentship, the student will acquire expertise in microbiology and glycobiology and in computational and in vivo skills. 

The student will benefit from the established network of international collaborations of the host Labs in this research area. Training will embrace research practice and theory, management, communication (to scientific and lay audiences), intellectual property, teamwork and technical writing. The student will present their work to internal seminars and to relevant Microbiology International meetings. The possible commercial issues relating to the impact of this research on human health will be highlighted and the student will be encouraged to participate into outreach activities and innovative competitions.

About NRP DTP:

The Norwich Research Park Biosciences Doctoral Training Partnership is open to UK and international candidates for entry October 2021 and offers postgraduates the opportunity to undertake a 4-year PhD research project whilst enhancing professional development and research skills through a comprehensive training programme. This project is short-listed for funding. 

Visit our website for further information:  

Person Specification: 

At least UK equivalence Bachelors (Honours) 2:1 or UK equivalence Master's degree. English Language requirement (Faculty of Science equivalent: IELTS 6.5 overall, 6 in each category). 

Funding Notes: 

This project is awarded with a 4-year Norwich Research Park Biosciences Doctoral Training Partnership (NRPDTP) PhD studentship. The studentship includes payment of tuition fees (directly to the University), a stipend for each year of the studentship (2020/21 stipend rate: £15,285), and a Research Training Support Grant for each year of the studentship of £5,000 p.a.

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